It's the End of Civilization as we know it. A mutagenic plague followed by a global war fought with disintegration weaponry has left much of the Earth a desert of fine powder and what remains of humanity fragmented into humans, animal-like mutants and bloodthirsty monstrosities with lots of teeth. The surface, still teeming with the mutagenic virus, has become the domain of the dreaded Topsiders; well-organized, technologically advanced, and heavily armed un-mutated humans sworn to exterminate mutations of any kind in order to clear the way for the eventual resurgence of a new, genetically clean humanity. Faced with annihilation, mutants and "impure" humans have retreated into the depths of the planet to form communities and hope to win, or at least survive, what may prove to be mankind's final war. Endtown is the continuing story of one of those communities.

The Comic follows the adventures of Cale'Anon and Richard, as well as their companions. Since its launch on November 26, 2006, it has received positive attention from the webcomics community at large.